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Ingredient · INCI reference

Acetyl Tetrapeptide-2

Acetyl Tetrapeptide-2 is a synthetic acetylated four-amino-acid peptide used as a skin-conditioning ingredient in anti-aging and supportive skincare formulas.

What it is

Acetyl Tetrapeptide-2 is a short signal-type peptide consisting of four amino acid residues with an acetyl group attached to improve stability and skin compatibility. It is incorporated into serums and sunscreens marketed for firmness and overall skin quality, where it functions as a conditioning agent. As with most cosmetic peptides, it is used at low concentrations within a supporting role rather than as a primary active.

Safety & warnings

Cosmetic peptides like Acetyl Tetrapeptide-2 are generally well tolerated at the low levels used in skincare and are not associated with significant irritation or sensitization for most users. They are water-soluble conditioning agents and are not considered comedogenic.

Origin & sourcing

Synthetic; manufactured by peptide synthesis that assembles a defined sequence of amino acids and caps the chain with an acetyl group.

Questions everyone asks

What is Acetyl Tetrapeptide-2 used for?

It is a peptide skin-conditioning ingredient added to serums and sunscreens, typically in formulas positioned around firmness and skin quality.

Is it natural or synthetic?

It is synthetic, produced by peptide synthesis to create a specific, stable four-amino-acid sequence.

Sources & references

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