Ozonized Glycerin — INCI reference

What it is

Ozonized Glycerin is produced by bubbling ozone gas through purified glycerin under controlled conditions, generating a mixture of glycerol, ozonides, and oxidized byproducts including peroxides, aldehydes, ketones, and organic acids. A key active species is a novel cyclic peroxide, 1,2,4-trioxepane, formed during ozonation. In cosmetics, it functions primarily as an astringent—contracting skin tissues and refining pore appearance—while also providing mild antimicrobial activity and supporting skin barrier function. Research suggests it may help reduce inflammation and assist wound closure. It is non-comedogenic (rated 0) and considered generally safe at concentrations typically used in cosmetic formulations. Stability requires refrigeration; the ingredient has an approximate half-life of 90 days at 2–8°C.

Safety & warnings

Generally considered safe for topical use at cosmetic concentrations. Non-comedogenic. Potential side effects include skin irritation, redness, and dryness, particularly in sensitive individuals; patch testing is recommended. Allergic reactions are uncommon but possible. Insufficient data on safety during pregnancy or breastfeeding; medical consultation advised in those cases. Most clinical evidence comes from small studies; regulatory status varies by market.

Origin & sourcing

Derived from glycerin (typically plant-sourced from coconut or soybean oils) by controlled ozonation: high-purity glycerin is bubbled with ozone gas at concentrations of 80–100 mg/L for up to seven days, then stabilized and stored in ozone-resistant glass. The base glycerin is largely plant-derived.

History

Ozone therapy dates to the late 19th century, but the cosmetic application of ozonized glycerin is more recent. A stable cream formulation was developed around 2004, and a patent established its stability and antimicrobial properties circa 2005. By 2022, a peer-reviewed clinical study demonstrated that OG-based cosmetic products could lighten age spots on human facial skin. In 2026, researchers at NC State University reported improved skin repair and barrier-support properties, highlighting the ingredient's growing relevance in dermocosmetics.

Questions everyone asks

What makes Ozonized Glycerin different from regular glycerin?

Regular glycerin is a humectant that attracts moisture to the skin. Ozonized Glycerin has been reacted with ozone, producing additional compounds such as ozonides and cyclic peroxides that contribute antimicrobial, astringent, and anti-inflammatory properties not present in plain glycerin.

What cosmetic benefits does Ozonized Glycerin provide?

It acts as an astringent to tighten skin and minimize pore appearance, provides mild antimicrobial activity, and emerging research suggests it may support skin barrier function, reduce inflammation, and help fade age spots due to its oxidative capacity.

Is Ozonized Glycerin safe to use in skincare?

At concentrations typically found in cosmetic products, it is considered generally safe. It is non-comedogenic and unlikely to clog pores. Sensitive skin types should patch test first, as irritation or dryness is possible.

How should products containing Ozonized Glycerin be stored?

Ozonized Glycerin is sensitive to heat and light. Formulated products should be stored in cool conditions; the raw ingredient requires refrigeration at 2–8°C to maintain activity, as it has an approximate half-life of 90 days under proper storage.