What it is
Palmitoyl hexapeptide-12 consists of a short chain of six amino acids linked to a palmitic acid (fatty acid) group, which improves its compatibility with the skin's lipid layers. It is used as a skin-conditioning agent in serums, creams, and other leave-on products, frequently marketed within peptide-focused formulas. It is typically used at very low concentrations.
Safety & warnings
Lipopeptides of this type are generally well tolerated and used at very low levels in leave-on products. They are not recognized fragrance allergens and are not comedogenic oils. As with any cosmetic ingredient, sensitive individuals may wish to patch test.
Origin & sourcing
Synthetic. The peptide portion is produced by controlled peptide synthesis and then acylated with palmitic acid to create the lipidated molecule.
Questions everyone asks
What is palmitoyl hexapeptide-12?
It is a synthetic peptide joined to a fatty acid, used as a skin-conditioning ingredient in leave-on skincare.
Does this peptide provide UV protection?
No. It is a conditioning ingredient and does not act as a UV filter or affect SPF.