What it is
Palmitoyl pentapeptide-4 is a five-amino-acid peptide (based on the KTTKS sequence) conjugated to palmitic acid so it can better associate with the skin's lipid surface. It is used as a skin-conditioning agent in anti-aging-positioned products, including some sunscreens, where it is included for its conditioning and moisture-supporting properties. It is typically used at very low concentrations.
Safety & warnings
Palmitoyl pentapeptide-4 is generally well tolerated and is used at low levels with a good cosmetic safety record. It is not a recognized fragrance allergen and is not associated with comedogenicity.
Origin & sourcing
Synthetic, produced by peptide synthesis and then attached to a palmitic-acid (fatty) chain to improve skin compatibility.
History
The KTTKS-based pentapeptide was commercialized under the Matrixyl trade name and became one of the most widely used cosmetic peptides in anti-aging skin care.
Questions everyone asks
What is palmitoyl pentapeptide-4 known as commercially?
It is best known under the Matrixyl trade name and is one of the most widely used peptides in anti-aging skin care.
Why is the peptide attached to palmitic acid?
The palmitic-acid chain makes the peptide more lipophilic so it can better associate with the skin's lipid surface.