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Ingredient · INCI reference

Palmitoyl Tripeptide-5

Palmitoyl Tripeptide-5 is a synthetic lipid-conjugated peptide used as a skin-conditioning agent in anti-aging and supportive skincare formulas.

What it is

Palmitoyl Tripeptide-5 is a short peptide chain joined to palmitic acid, which improves its compatibility with the skin's lipid barrier and helps it penetrate the upper layers of skin. The palmitoyl group makes the otherwise water-soluble peptide more lipophilic so it can be delivered in conditioning and treatment formulas. In sunscreens it is typically a minor conditioning ingredient that supports a smooth, well-cared-for skin feel.

Safety & warnings

Palmitoyl Tripeptide-5 is used at very low concentrations and is generally well tolerated topically. It is not a recognized fragrance allergen and is not considered notably comedogenic at typical use levels.

Origin & sourcing

It is a fully synthetic ingredient, manufactured by chemically conjugating a defined tripeptide sequence to palmitic acid.

Questions everyone asks

What is the palmitoyl part for?

The palmitic-acid group makes the water-soluble peptide more lipid-friendly, improving its compatibility with the skin barrier and its delivery in a formula.

Is Palmitoyl Tripeptide-5 a UV filter?

No. It is a skin-conditioning peptide, not a UV filter, and provides no sun protection on its own.

Sources & references

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