What it is
sh-Decapeptide-5 is a single-chain synthetic human peptide consisting of ten amino acids—including arginine, asparagine, cysteine, glutamine, lysine, tryptophan, and tyrosine—designed to be structurally identical to a portion of the human protein eosinophil cationic protein (ECP). In cosmetic formulations, it is used as a skin-conditioning and skin-protecting ingredient, helping to maintain and support the skin's surface condition while providing a degree of protection against external environmental factors. As a cell-penetrating peptide class ingredient, it can facilitate the transdermal uptake of active compounds. It is commonly found in anti-aging serums, moisturizers, and tonics, often paired with vitamins B3, B5, and E to address skin elasticity and appearance.
Safety & warnings
No specific safety concerns or sensitization data are widely reported for sh-Decapeptide-5 in the published literature or major cosmetic ingredient safety databases. Related decapeptides derived from human proteins have shown low irritation and non-sensitizing profiles in standardized OECD testing. No evidence of comedogenicity or known allergens identified in available sources.
Origin & sourcing
Produced by solid-phase chemical peptide synthesis to replicate a naturally occurring 10-amino-acid sequence found in human eosinophil cationic protein. No animal-derived raw materials are required for the synthesis process.
Questions everyone asks
What does the 'SH-' prefix mean in sh-Decapeptide-5?
The 'SH-' prefix in INCI nomenclature stands for 'single-chain human,' indicating that the peptide is a synthetically produced single-chain sequence identical to a fragment of a naturally occurring human protein.
What is eosinophil cationic protein, and why is it relevant?
Eosinophil cationic protein (ECP) is a human ribonuclease with known cell-penetrating and antimicrobial properties. sh-Decapeptide-5 is designed to mimic a portion of ECP, which may contribute to its ability to interact with skin cells and support conditioning effects.
Is sh-Decapeptide-5 the same as sh-Decapeptide-5 SP?
sh-Decapeptide-5 SP (single-chain, phosphorylated or salt-paired variant) is a closely related INCI name found in cosmetic ingredient databases. The core peptide sequence is the same; 'SP' designates a specific chemical form used in formulation.
In what types of products is sh-Decapeptide-5 used?
It appears in serums, toners, ampoules, and moisturizing creams, particularly products marketed for calming, soothing, and anti-aging benefits. It is often combined with other bioactive peptides and vitamins.