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Ingredient · INCI reference

sh-Polypeptide-22

A synthetic, bioengineered polypeptide used in skincare as a skin-conditioning ingredient.

What it is

sh-Polypeptide-22 is a synthetic human-identical polypeptide produced through recombinant biotechnology, with the sh prefix denoting a synthetic version of a human protein sequence. In cosmetics it is used as a skin-conditioning ingredient and is often included in growth-factor-style formulations. It is a supporting peptide and does not act as a UV filter.

Safety & warnings

Bioengineered polypeptides of this type are generally well tolerated at cosmetic use levels. Irritation or sensitization is uncommon but possible, and any stabilizers or preservatives in the accompanying raw material may also contribute to reactions.

Origin & sourcing

Synthetic; manufactured by recombinant biotechnology (typically microbial fermentation) to produce a peptide matching a human protein sequence, not extracted from human tissue.

Questions everyone asks

What does sh-Polypeptide-22 do?

It functions as a skin-conditioning ingredient and is a supporting component in formulas, often associated with peptide and growth-factor-style products.

Is sh-Polypeptide-22 derived from humans?

No. Despite the human in synthetic human, it is made by biotechnology to match a human protein sequence and is not sourced from human tissue.

Sources & references

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