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La Roche-Posay Anthelios UVmune 400 Cream SPF 50+
La Roche-Posay

Anthelios UVmune 400 Cream SPF 50+

SPF 50+ Invisible No white cast — chemical/hybrid filters that straight-up disappear on skin. Europe global Formulation variant: global. Region-specific reformulations are tracked as separate products.

Robust modern EU filter suite, no fragrance, elegant fluid texture; alcohol denat positioned third tempers sensitive-skin score.

◐ CHEM Chemical filters Chemical filters — Organic filters absorb UV. Cosmetically elegant, but filter choice matters. ((· BS Broad spectrum Broad spectrum — Blocks UVA + UVB — covers the whole sun-damage spectrum. F F-FREE Fragrance-free Fragrance-free — No added fragrance — lower irritation risk if your skin's reactive.
Where to buy it
YesStyle US In stock
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79.6
Composite
Composite score · independent
Ranks #358 of 1558 in the current catalogue. Robust modern EU filter suite, no fragrance, elegant fluid texture; alcohol denat positioned third tempers sensitive-skin score.
Composite is a weighted blend: UV 25% · Modernity 10% · Sensitivity 15% · Environment 10% · Elegance 15% · Health 25%. That's the recipe.
01 The score breakdown
UV protection How hard it blocks UVA + UVB across the spectrum at the stated SPF/PA. 85
Filter modernity Dings legacy filters (octinoxate, oxybenzone); rewards photostable next-gen ones. 86
Sensitivity safety Risk for reactive skin — fragrance, alcohol, and known sensitisers. 58
Reef / env. safety Reef toxicity plus how biodegradable the UV filters and surfactants are. 100
Cosmetic elegance Spread, finish, white-cast, and how it actually feels on skin. 80
Health safety Endocrine concerns and systemic absorption signals across the whole formula. 76
02 Composition · key UV filters 8 filters resolved
UVA-I 340–400nm UVA-I (340–400nm) — covered UVA-II 320–340nm UVA-II (320–340nm) — covered UVB 290–320nm UVB (290–320nm) — covered
Octisalate Legacy Older organic filter. Photostable in combination; some literature concerns.
Uvinul T 150 Modern Next-gen photostable filter; low irritation profile.
Bemotrizinol Modern Next-gen photostable filter; low irritation profile.
Mexoryl XL Modern Next-gen photostable filter; low irritation profile.
Avobenzone Legacy Older organic filter. Photostable in combination; some literature concerns.
Mexoryl 400 (MCE) Modern Next-gen photostable filter; low irritation profile.
Uvinul A Plus Modern Next-gen photostable filter; low irritation profile.
Ecamsule (Mexoryl SX) Modern Next-gen photostable filter; low irritation profile.
03 The facts, at a glance
Protection
Filter type Mineral filters (zinc oxide, titanium dioxide) sit on skin and reflect UV. Chemical filters absorb UV. Hybrid runs both.
Chemical
Broad spectrum Covers both UVA and UVB. UVA drives aging and deeper damage; UVB gives you burns.
Yes
Formulation & feel
Texture How it feels going on — milk, gel, cream, spray, stick, essence, lotion, powder, or cushion.
Cream
Finish How it looks once dry: matte, natural, dewy, or glowy.
Natural
Tinted Adds sheer pigment (iron oxides) that masks the white cast common to mineral filters and gives a skin-tone finish.
No
Fragrance-free No synthetic perfume added. Not FDA-defined in the US; the EU requires 'Parfum' + the 26 named allergens on the label. 'Unscented' is different — it can hide masking fragrance. Botanical oils still scent.
Yes
Alcohol-free No drying short-chain alcohols (alcohol denat., SD alcohol, ethanol). Doesn't mean fatty alcohols like cetyl or stearyl — those are emollients.
No
Verdict Is it worth it?

The flagship EU Uvmune cream stacks Mexoryl 400 with bemotrizinol, Uvinul T 150 and a full long-UVA toolkit for strong, modern protection. Alcohol denat sits third in the list, tempering wearability for reactive skin.

Pros
  • Eight-filter modern EU system
  • Mexoryl 400 covers long UVA
  • Fragrance-free formulation
  • Elegant fluid-cream texture
  • Tocopherol and stabilizing antioxidants
Cons
  • Alcohol denat high in the list
  • Triethanolamine present
  • No PA rating provided
  • Not suitable for alcohol-averse skin

Who it's for: Buyers wanting top-tier UVA-I coverage in a refined cream and willing to accept denatured alcohol for the finish.

04 Full ingredient list (INCI) 27 ingredients
MODERN FILTER 6 LEGACY FILTER 2 MINERAL FILTER 0 ADDED FRAGRANCE 0 NATURAL FRAGRANCE 0 ALCOHOL 1 WATCH 0 ACTIVE 2
Water·Diisopropyl Sebacate· Alcohol Denat. Drying short-chain alcohol — can compromise the skin barrier and disturb the film if used in high amounts. · Ethylhexyl Salicylate Octisalate — older filter; well-tolerated. · Ethylhexyl Triazone Uvinul T 150 — high-efficiency UVB filter. · Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine Tinosorb S — broad-spectrum, very photostable. ·Diisopropyl Adipate·Peg-8·Dipropylene Glycol·C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer· Glycerin Humectant — the workhorse hydrator. · Drometrizole Trisiloxane Mexoryl XL ·Aluminum Starch Octenylsuccinate· Butyl Methoxydibenzoylmethane Avobenzone — UVA filter, needs stabilisation. · Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate Mexoryl 400 (MCE) ·Silica· Tocopherol Vitamin E — antioxidant. · Diethylamino Hydroxybenzoyl Hexyl Benzoate Uvinul A Plus — modern photostable UVA filter. ·Acrylates Copolymer·Acrylates/C10-30 Alkyl Acrylate Crosspolymer·Caprylyl Glycol·Hydroxyacetophenone·Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate·Sodium Polyacrylate· Terephthalylidene Dicamphor Sulfonic Acid Ecamsule (Mexoryl SX) ·Triethanolamine·Trisodium Ethylenediamine Disuccinate
Source: brand-published INCI. Last verified 2026. Show in detail
01 Water Water
02 Diisopropyl Sebacate Diisopropyl Sebacate
03 Alcohol Denat. ALCOHOL Drying short-chain alcohol — can compromise the skin barrier and disturb the film if used in high amounts.
04 Ethylhexyl Salicylate LEGACY FILTER Octisalate — older filter; well-tolerated.
05 Ethylhexyl Triazone MODERN FILTER Uvinul T 150 — high-efficiency UVB filter.
06 Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine MODERN FILTER Tinosorb S — broad-spectrum, very photostable.
07 Diisopropyl Adipate Diisopropyl Adipate
08 Peg-8 PEG-8
09 Dipropylene Glycol Dipropylene Glycol
10 C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer
11 Glycerin ACTIVE Humectant — the workhorse hydrator.
12 Drometrizole Trisiloxane MODERN FILTER Mexoryl XL
13 Aluminum Starch Octenylsuccinate Aluminum Starch Octenylsuccinate
14 Butyl Methoxydibenzoylmethane LEGACY FILTER Avobenzone — UVA filter, needs stabilisation.
15 Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate MODERN FILTER Mexoryl 400 (MCE)
16 Silica Silica
17 Tocopherol ACTIVE Vitamin E — antioxidant.
18 Diethylamino Hydroxybenzoyl Hexyl Benzoate MODERN FILTER Uvinul A Plus — modern photostable UVA filter.
19 Acrylates Copolymer Acrylates Copolymer
20 Acrylates/C10-30 Alkyl Acrylate Crosspolymer Acrylates/C10-30 Alkyl Acrylate Crosspolymer
21 Caprylyl Glycol Caprylyl Glycol
22 Hydroxyacetophenone Hydroxyacetophenone
23 Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate
24 Sodium Polyacrylate Sodium Polyacrylate
25 Terephthalylidene Dicamphor Sulfonic Acid MODERN FILTER Ecamsule (Mexoryl SX)
26 Triethanolamine Triethanolamine
27 Trisodium Ethylenediamine Disuccinate Trisodium Ethylenediamine Disuccinate